962 Administration of IL-31 induces anxiety-like behavior in mice

Atopic dermatitis (AD) is a chronic, recurrent, itchy eczematous disorder associated with impaired skin barrier functions. The coexistence of anxiety, depression, and social withdrawal problematic in AD. At present, psychological factors such as stigma resulting from appearance insomnia pruritus are possible causes, but the detailed causes depression anxiety AD unknown. Here we hypothesized that chronic may induce mental disorders. To this end, examined state mice treated IL-31, cytokine induces characteristic We administered IL-31 or vehicle continuously for 23 days at dose 2 μg/day by inserting an osmotic pump under on back C57BL/6J mice. assessed murine Open Field Test (OFT) Light/Dark Transition (LDTT). observe behavioral alterations short-term long-term administration, conducted LDTT day 8 19 OFT 9 20 after beginning administration. IL-31-treated exhibited scratching behavior, no erythema other was observed. group showed significantly more severe than control 20. In addition, significant difference 8, while 19, IL-31-administrated behavior compared to group. summary, administration found increase tendencies. These results suggest caused involved